ISDA: 9QNU

Deposition Date 2025-03-25

Release Date 2026-06-24

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9QNU

Keywords:

DE NOVO PROTEIN

Title:

Crystal structure of Nanofitin C10 - fused to a coiled-coil domain - in complex with a C2 symmetric 31unit aromatic oligoamide foldamer

Biological Source:

Source Organism(s):

Sulfolobus acidocaldarius (Taxon ID: 2285)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.53 Å

R-Value Free:

0.26

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

I 41 2 2

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Foldamer-binding Nanofitin C1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Sulfolobus acidocaldarius

Structural Superimposition Protein Blast

Polymer Type:polypeptide(D)
Molecule:Aromatic oligoamide foldamer
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

A protein-foldamer supramolecular synthon for self-assembled hybrid architectures.

Sigl, J, Morozov, V, Wang, L, Sachs, J, Merlet, E, Largy, E, Geue, N, Osterlund, N, Kwon, S, Sanchez, F, Candela, L, Huet, S, Pagel, K, Ferrand, Y, Douat, C, Mackereth, C.D, Huc, I.Show

Nat.Chem. ? ? ? (2026)

PMID: 42608459 DOI: 10.1038/s41557-026-02222-6

Primary Citation of related structures

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