ISDA: 9QK2

Deposition Date 2025-03-19

Release Date 2025-12-24

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9QK2

Keywords:

IMMUNE SYSTEM

Title:

Structure of the Complement classical and lectin pathway C3 convertase in complex with substrate C3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Homo sapiens, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Complement C4-A
Gene (Uniprot):C4A
Chain IDs:A, B (auth: C), D (auth: B)
Chain Length:1744
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P0C0L4 Pfam ID:PF21145, PF01835, PF17791, PF17789, PF07703, PF01821, PF00207, PF07678, PF22661, PF07677, PF01759

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Anti-C4b nanobody B12
Chain IDs:E (auth: D)
Chain Length:120
Number of Molecules:1
Biological Source:Lama glama

UniProt ID:9QK2

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Complement C2
Gene (Uniprot):C2
Chain IDs:C (auth: E)
Chain Length:752
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P06681 Pfam ID:PF00084, PF00092, PF00089

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Complement C3
Gene (Uniprot):C3
Chain IDs:F, G
Chain Length:1663
Number of Molecules:2
Biological Source:Homo sapiens