ISDA: 9QFC

Deposition Date 2025-03-11

Release Date 2026-01-14

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9QFC

Keywords:

TRANSFERASE

Title:

Tankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.55 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Poly [ADP-ribose] polymerase
Gene (Uniprot):TNKS2
Chain IDs:A, B
Chain Length:162
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9H2K2 Pfam ID:PF12796 EC:2.4.2.30,2.4.2.-

Ligand Molecules

A1I5S

A1I6W

PEG

Primary Citation

Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain.

Bosetti, C, Galera-Prat, A, Sowa, S.T, Gade, A, Braga, C, Brinch, S.A, Nami, F, Paakkonen, J, Pulju, V, Meling, M.T, Candamo-Lourido, M, Waaler, J, Clausen, M.H, Lehtio, L.Show

Structure 34 471 486.e7 (2026)

PMID: 41619733 DOI: 10.1016/j.str.2025.12.015

Primary Citation of related structures

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