ISDA: 9QE8

Deposition Date 2025-03-07

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9QE8

Keywords:

TRANSCRIPTION

Title:

SMAD4 MH2 domain (residues 314-552) bound by Nanobody A7 (NbA7)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.04 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mothers against decapentapleg
Gene (Uniprot):SMAD4
Chain IDs:A, C, E, G, I, K
Chain Length:0
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:Q13485 Pfam ID:PF03166

Polymer Type:polypeptide(L)
Molecule:Nanobody A7 (NbA7)
Chain IDs:B, D, F, H, J, L
Chain Length:0
Number of Molecules:6
Biological Source:Lama glama

Ligand Molecules

ACT

EDO

PEG

Primary Citation

(RUNNING TITLE:) Nanobodies for SMAD4 Structural and Functional Studies

Condeminas, M, Torner, C, Pluta, R, Ruiz, L, Aragon, E, Rodriguez de Regil, M, Martin-Malpartida, P, Pardon, E, Steyaert, J, Macias, M.J.Show

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