ISDA: 9Q9Q

Deposition Date 2025-02-26

Release Date 2025-10-08

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9Q9Q

Keywords:

LIGASE

Title:

TRIM21 PRYSPRY bound to compound 38

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.25 Å

R-Value Free:

0.32

R-Value Work:

0.25

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase T
Gene (Uniprot):TRIM21
Chain IDs:A (auth: B), B (auth: A)
Chain Length:198
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P19474 Pfam ID:PF13765, PF00622

Ligand Molecules

A1I4Y

Primary Citation

State-selective small molecule degraders that preferentially remove aggregates and oligomers.

Luptak, J, Clift, D, Mukadam, A, Benn, J, Rhinesmith, T, McLaughlin, S.H, Dodds, A.C, Lapetaje, J.E, Sczaniecka-Clift, M, France, D.J, McEwan, W.A, James, L.C.Show

Nat Commun 16 10486 10486 (2025)

PMID: 41290659 DOI: 10.1038/s41467-025-65454-z

Primary Citation of related structures

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