9Q8V image
Deposition Date 2025-02-25
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9Q8V
Keywords:
IMMUNE SYSTEM
Title:
Cryo-EM structure of the NLRP3 decamer bound to the inhibitor BAL-1516
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.06 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Q8V validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:NACHT, LRR and PYD domains-co
Gene (Uniprot):NLRP3
Chain IDs:A, B, C, D, E, F, G, H, I, J
Chain Length:1036
Number of Molecules:10
Biological Source:Homo sapiens
UniProt ID:Q96P20 Pfam ID:PF02758, PF14484, PF05729, PF17779, PF17776, PF13516
Ligand Molecules
A1I4G
ADP
MG
Primary Citation
Inhibition of NLRP3 by a CNS-penetrating indazole scaffold
To Be Published ? ? ? (?)
Primary Citation of related structures
9IHN
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