ISDA: 9Q3L

Deposition Date 2025-08-18

Release Date 2026-08-19

Last Version Date 2026-10-14

Entry Detail

PDB ID:

9Q3L

Keywords:

SIGNALING PROTEIN

Title:

CryoEM structure of beta2-adrenergic receptor dimer mediated by a biased allosteric modulator in lipid nanodisc

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2 adrenergic receptor
Gene (Uniprot):ADRB2
Chain IDs:A, B
Chain Length:460
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P07550 Pfam ID:PF00001

Ligand Molecules

A1CNS

C14

LFA

P0G

Primary Citation

A biased allosteric modulator is a molecular glue for beta 2 AR dimerization.

Shen, J, Peddada, T.N, Komolov, K.E, De Pascali, F, Garces, A.M, Wang, H, Ehsan, M, Chae, P.S, Lerch, M.T, Benovic, J.L, Xu, J, Kobilka, B.K.Show

Nature 658 556 564 (2026)

PMID: 42618785 DOI: 10.1038/s41586-026-10892-y

Primary Citation of related structures

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