ISDA: 9Q2T

Deposition Date 2025-08-15

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

9Q2T

Keywords:

RIBOSOME

Title:

NediV IRES in complex with Rabbit 80S ribosome with eEF2 and P site Ala-tRNA

Biological Source:

Source Organism(s):

Oryctolagus cuniculus (Taxon ID: 9986)
Nedicistrovirus TFN-2012 (Taxon ID: 1228014)

Expression System(s):

Oryctolagus cuniculus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:NediV IRES
Chain IDs:DC (auth: 1)
Chain Length:0
Number of Molecules:1
Biological Source:Nedicistrovirus TFN-2012

Polymer Type:polyribonucleotide
Molecule:28S rRNA
Chain IDs:AC (auth: 5)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:5S rRNA
Chain IDs:BC (auth: 7)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:5.8S rRNA
Chain IDs:CC (auth: 8)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:18S rRNA
Chain IDs:R (auth: 9)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L8
Gene (Uniprot):RPL8
Chain IDs:KA (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TT27 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S_SA_C domain-containing pr
Chain IDs:S (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TJH8 Pfam ID:PF00318

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Gene (Uniprot):RPL3
Chain IDs:LA (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TL06 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3a
Gene (Uniprot):RPS3A
Chain IDs:T (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SS70 Pfam ID:PF01015

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L4
Chain IDs:MA (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A5F9DCT1 Pfam ID:PF00573, PF14374

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S2
Gene (Uniprot):RPS2
Chain IDs:U (auth: CC)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:O18789 Pfam ID:PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L5
Gene (Uniprot):RPL5
Chain IDs:NA (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P19949 Pfam ID:PF17144, PF14204

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3
Gene (Uniprot):RPS3
Chain IDs:A (auth: DD)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TNM3 Pfam ID:PF07650, PF00189 EC:4.2.99.18

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL6
Chain IDs:OA (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SKF7 Pfam ID:PF03868, PF01159

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S4
Chain IDs:V (auth: EE)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TA47 Pfam ID:PF08071, PF00900, PF00467, PF16121

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongation factor 2
Gene (Uniprot):EEF2
Chain IDs:FC (auth: EF)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P55823 Pfam ID:PF00009, PF03144, PF14492, PF03764, PF00679 EC:3.6.5.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7
Gene (Uniprot):RPL7
Chain IDs:PA (auth: F)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SV32 Pfam ID:PF08079, PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS5
Chain IDs:B (auth: FF)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TFM5 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL7A
Chain IDs:QA (auth: G)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1STW0 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:W (auth: GG)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TM55 Pfam ID:PF01092

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L9
Gene (Uniprot):RPL9
Chain IDs:RA (auth: H)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SWI6 Pfam ID:PF00347

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS7
Chain IDs:X (auth: HH)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SVB0 Pfam ID:PF01251

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L10
Gene (Uniprot):RPL10
Chain IDs:SA (auth: I)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:B7NZQ2 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):RPS8
Chain IDs:Y (auth: II)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TJW1 Pfam ID:PF01201

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L11
Gene (Uniprot):RPL11
Chain IDs:TA (auth: J)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TUB8 Pfam ID:PF00281, PF00673

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S9
Gene (Uniprot):RPS9
Chain IDs:Z (auth: JJ)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:B7NZS8 Pfam ID:PF00163, PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S10
Chain IDs:C (auth: KK)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TPV3 Pfam ID:PF03501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL13
Chain IDs:UA (auth: L)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TKB3 Pfam ID:PF01294

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS11
Chain IDs:AA (auth: LL)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TRM4 Pfam ID:PF16205, PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L14
Gene (Uniprot):RPL14
Chain IDs:VA (auth: M)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SZ12 Pfam ID:PF01929

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:D (auth: MM)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SFR8 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L15
Gene (Uniprot):RPL15
Chain IDs:WA (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T0C1 Pfam ID:PF00827

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S13
Gene (Uniprot):RPS13
Chain IDs:BA (auth: NN)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SP51 Pfam ID:PF08069, PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL13A
Chain IDs:XA (auth: O)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TVS8 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS14
Chain IDs:CA (auth: OO)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T1F0 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L17
Gene (Uniprot):RPL17
Chain IDs:YA (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SCJ6 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS15
Chain IDs:E (auth: PP)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U0Q2 Pfam ID:PF00203

Polymer Type:polyribonucleotide
Molecule:ala-tRNA
Chain IDs:EC (auth: PT)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL18
Chain IDs:ZA (auth: Q)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TFE0 Pfam ID:PF17135

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS16
Chain IDs:F (auth: QQ)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SGX4 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L19
Gene (Uniprot):RPL19
Chain IDs:P (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TYL6 Pfam ID:PF01280, PF25476

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S17
Gene (Uniprot):RPS17
Chain IDs:G (auth: RR)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TU13 Pfam ID:PF00833

Polymer Type:polypeptide(L)
Molecule:eL20
Chain IDs:AB (auth: S)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S18
Gene (Uniprot):RPS18
Chain IDs:H (auth: SS)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TPG3 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L21
Gene (Uniprot):RPL21
Chain IDs:BB (auth: T)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SHQ2 Pfam ID:PF01157

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS19
Chain IDs:I (auth: TT)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TN62 Pfam ID:PF01090

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL22
Chain IDs:CB (auth: U)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TSG1 Pfam ID:PF01776

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Gene (Uniprot):RPS20
Chain IDs:J (auth: UU)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SIZ2 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL23
Chain IDs:DB (auth: V)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T6D1 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:eS21
Gene (Uniprot):RPS21
Chain IDs:DA (auth: VV)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TM82 Pfam ID:PF01249

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):LOC100346954
Chain IDs:Q (auth: W)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A5F9D1W0 Pfam ID:PF01246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15a
Gene (Uniprot):RPS15A
Chain IDs:EA (auth: WW)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TG89 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL23A
Chain IDs:EB (auth: X)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SE76 Pfam ID:PF03939, PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S23
Gene (Uniprot):RPS23
Chain IDs:FA (auth: XX)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SZ47 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L26
Gene (Uniprot):RPL26
Chain IDs:FB (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SQH0 Pfam ID:PF16906, PF00467

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):LOC100338405
Chain IDs:GA (auth: YY)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T3D8 Pfam ID:PF01282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):RPL27
Chain IDs:GB (auth: Z)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TXF6 Pfam ID:PF00467, PF01777

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:K (auth: ZZ)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TDB3 Pfam ID:PF03297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27a
Gene (Uniprot):RPL27A
Chain IDs:HB (auth: a)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SNY0 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:eS26
Gene (Uniprot):RPS26
Chain IDs:HA (auth: aa)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TFE8 Pfam ID:PF01283

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL29
Chain IDs:IB (auth: b)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SGR6 Pfam ID:PF01779

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):RPS27
Chain IDs:IA (auth: bb)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TZ76 Pfam ID:PF01667

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L30
Gene (Uniprot):RPL30
Chain IDs:JB (auth: c)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TDL2 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Gene (Uniprot):RPS28
Chain IDs:L (auth: cc)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TIB4 Pfam ID:PF01200

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L31
Gene (Uniprot):RPL31
Chain IDs:KB (auth: d)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SHG0 Pfam ID:PF01198

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S29
Gene (Uniprot):RPS29
Chain IDs:M (auth: dd)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U7M4 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL32
Chain IDs:LB (auth: e)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TUN8 Pfam ID:PF01655

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):FAU
Chain IDs:JA (auth: ee)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T8A2 Pfam ID:PF04758

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL35A
Chain IDs:MB (auth: f)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SF08 Pfam ID:PF01247

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27a
Gene (Uniprot):RPS27A
Chain IDs:N (auth: ff)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SK22 Pfam ID:PF01599

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L34
Gene (Uniprot):RPL34
Chain IDs:NB (auth: g)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TXG5 Pfam ID:PF01199

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Receptor of activated protein
Gene (Uniprot):RACK1
Chain IDs:O (auth: gg)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SJB4 Pfam ID:PF00400

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35
Gene (Uniprot):RPL35
Chain IDs:OB (auth: h)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SIT5 Pfam ID:PF00831

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Gene (Uniprot):RPL36
Chain IDs:PB (auth: i)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TTQ5 Pfam ID:PF01158

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L37
Gene (Uniprot):RPL37
Chain IDs:QB (auth: j)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:U3KPD5 Pfam ID:PF01907

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL38
Chain IDs:RB (auth: k)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U001 Pfam ID:PF01781

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L39
Gene (Uniprot):LOC100343258
Chain IDs:SB (auth: l)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TTN1 Pfam ID:PF00832

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):UBA52
Chain IDs:TB (auth: m)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P0DXC2 Pfam ID:PF01020

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:eL41
Gene (Uniprot):RPL41
Chain IDs:UB (auth: n)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A087WNH4 Pfam ID:PF05162

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:eL42
Chain IDs:VB (auth: o)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A5F9D391 Pfam ID:PF00935

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L37a
Gene (Uniprot):RPL37A
Chain IDs:WB (auth: p)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SY53 Pfam ID:PF01780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L28
Gene (Uniprot):RPL28
Chain IDs:XB (auth: r)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U7L1 Pfam ID:PF01778

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S acidic ribosomal protein
Gene (Uniprot):RPLP0
Chain IDs:YB (auth: s)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SPK4 Pfam ID:PF00466, PF17777

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL11
Gene (Uniprot):RPL12
Chain IDs:ZB (auth: t)
Chain Length:0
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SMR7 Pfam ID:PF03946, PF00298

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
DDE	FC	HIS	modified residue

Ligand Molecules

Primary Citation

Structural studies of nedicistrovirus IRES-driven, initiation factor-independent translation shed light on key steps of eukaryotic translation elongation.

De, S, Altomare, C.G, Abaeva, I.S, Dadhwal, P, Garg, P, Acosta-Reyes, F, Brown, Z.P, Pestova, T.V, Hellen, C.U.T, Frank, J.Show

Nucleic Acids Res. 54 ? ? (2026)

PMID: 42240621 DOI: 10.1093/nar/gkag510

Abstact

We utilized the nedicistrovirus (NediV) intergenic region (IGR) internal ribosomal entry site (IRES)-mediated, initiation factor-independent translation initiation system and determined high-resolution structures of 80S ribosome complexes with the NediV IRES in various functional states, including binary complexes, aminoacyl-transfer RNA (tRNA)-bound complexes, and complexes with elongation factor eEF2. In binary complexes, the NediV IRES primarily occupies the ribosomal P site, exhibiting conformational flexibility and engaging the ribosome at multiple interaction sites. Upon translocation, the IRES undergoes structural rearrangements, including destabilization of its PKI domain, facilitating the transition to canonical elongation. Crucially, we captured an eEF2-bound complex, along with an eEF1A-bound failed decoding complex featuring a mismatched tRNA, the latter representing the first instance of a canonical elongation complex visualized in the presence of a natural, hydrolysable nucleotide and without the addition of any trapping agents. These findings provide a comprehensive structural overview of IGR IRES-mediated translation initiation and its transition to elongation, revealing key mechanistic details of viral translation and proofreading.

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Disease

Primary Citation of related structures

Abstact

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