9Q0O image
Deposition Date 2025-08-13
Release Date 2026-06-03
Last Version Date 2026-06-03
Entry Detail
PDB ID:
9Q0O
Keywords:
BIOSYNTHETIC PROTEIN
Title:
Cryo-EM structure of PPAT-NUDT5 complex bound to 6-benzylthioinosine-5'-monophosphate (6-benzylTIMP)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Q0O validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Amidophosphoribosyltransferas
Gene (Uniprot):PPAT
Chain IDs:A, B, C, D
Chain Length:552
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q06203 Pfam ID:PF13522, PF00156 EC:2.4.2.14
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ADP-sugar pyrophosphatase
Gene (Uniprot):NUDT5
Mutagens:Y74F
Chain IDs:E, F, G, H
Chain Length:223
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9UKK9 Pfam ID:PF00293 EC:2.7.7.96
Ligand Molecules
A1CQ4
SF4
Primary Citation
Regulation of purine synthesis and chemotherapy response by metabolite-derived molecular glues
To Be Published ? ? ? (?)
Primary Citation of related structures
9Q0N
9Q0M
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