ISDA: 9PZ3

Deposition Date 2025-08-08

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9PZ3

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of HIV Apex targeting neutralizing antibody Q12BBM-069

Biological Source:

Source Organism(s):

Macaca mulatta (Taxon ID: 9544)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fab Q12BBM-069 heavy chain
Chain IDs:A
Chain Length:235
Number of Molecules:1
Biological Source:Macaca mulatta

UniProt ID:9PZ3

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fab Q12BBM-069 light chain
Chain IDs:B
Chain Length:212
Number of Molecules:1
Biological Source:Macaca mulatta

UniProt ID:9PZ3

Primary Citation

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex.

Guenaga, J, Adori, M, Bale, S, Phulera, S, Zygouras, I, Schleich, F.A, Castro Dopico, X, Agrawal, S, Ota, M, Wilson, R, Cluff, J, Dzvelaia, T, Mandolesi, M, Lee, W.H, Walsh, A.A, Melo, M.B, Verkoczy, L, Irvine, D.J, Corcoran, M, Wilson, I.A, Carnathan, D, Silvestri, G, Ward, A.B, Ozorowski, G, Karlsson Hedestam, G.B, Wyatt, R.T.Show

Nature ? ? ? (2026)

PMID: 42056526 DOI: 10.1038/s41586-026-10429-3

Primary Citation of related structures

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