ISDA: 9PW3

Deposition Date 2025-08-04

Release Date 2026-03-18

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9PW3

Keywords:

PROTEIN FIBRIL

Title:

Cryo-EM structure of renal amyloid fibril from a variant apolipoprotein A-I R173P amyloidosis patient

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.73 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Apolipoprotein A-I
Gene (Uniprot):APOA1
Chain IDs:A, B, C, D, E, F, G, H, I, J
Chain Length:243
Number of Molecules:10
Biological Source:Homo sapiens

UniProt ID:P02647 Pfam ID:PF01442

Ligand Molecules

Primary Citation

Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations.

Nguyen, B.A, Fernandez-Ramirez, M.D.C, Bassett, P, Singh, V, Singh, P, Pekala, M, Villalon, L, Ahmed, Y, Lemoff, A, Evers, B, Lopez, C, Kluve-Beckerman, B, Saelices, L.Show

Nat Commun ? ? ? (2026)

PMID: 41991931 DOI: 10.1038/s41467-026-72150-z

Primary Citation of related structures

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