ISDA: 9PVM

Deposition Date 2025-08-01

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9PVM

Keywords:

MEMBRANE PROTEIN

Title:

cryoEM structure of drug bound human SLC33A1 transporter

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.27 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Acetyl-coenzyme A transporter
Mutagens:no
Chain IDs:A
Chain Length:580
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1CTY

Y01

Primary Citation

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.

Kutseikin, S, Rafiq, M, Bora, P, Liu, S, Homan, R.A, Mindrebo, J.T, Holcomb, M, Petrassi, H.M, Qiu, H, Redkina, A, Sosna, J, Lee, T.T, Hu, X, Forli, S, Parker, C.G, Lander, G.C, Birsoy, K, Saez, E, Wiseman, R.L.Show

Biorxiv ? ? ? (2026)

PMID: 41757008 DOI: 10.64898/2026.02.17.706344

Primary Citation of related structures

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