ISDA: 9PV0

Deposition Date 2025-07-31

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9PV0

Keywords:

TRANSPORT PROTEIN/INHIBITOR

Title:

NorA in outward-open conformation bound to inhibitor IMP2380

Biological Source:

Source Organism(s):

Staphylococcus aureus (Taxon ID: 1280)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.52 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Quinolone resistance protein
Gene (Uniprot):cybC, norA
Chain IDs:A (auth: Z)
Chain Length:495
Number of Molecules:1
Biological Source:Staphylococcus aureus, Escherichia coli

UniProt ID:Q5HHX4,P0ABE7

Ligand Molecules

A1CLB

Primary Citation

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

Gray, J.L, Ledger, E.V.K, Suwatthee, T, Lanyon-Hogg, T, Burden, T.J, Arvaniti, K, Sefton, A, Papagora, L.E, Clarke, T.B, Riley, J, Pinto, E.G, Cunningham, F, Gilbert, I.H, Gray, D, Wang, D, Read, K.D, Traaseth, N.J, Edwards, A, Tate, E.W.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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