ISDA: 9PPL

Deposition Date 2025-07-21

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9PPL

Keywords:

IMMUNE SYSTEM

Title:

Structure of STING in complex with MK-2118

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.01 Å

R-Value Free:

0.18

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Stimulator of interferon gene
Gene (Uniprot):STING1
Chain IDs:A
Chain Length:188
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q86WV6 Pfam ID:PF15009

Ligand Molecules

A1CIY

Primary Citation

Discovery of MK-2118, a Small-Molecule Agonist of STING

Henderson, T, Altman, M.D, Buevich, A.V, Cash, B, Cemerski, S, Chang, W, Chen, Y, Childers, M, Cumming, J, Dandliker, P.J, Feng, G, Haidle, A, Hayes, R.P, Ho, T, Jewell, J.P, Kariv, I, Knemeyer, I, Kopinja, J, Lacey, B.M, Laskey, J, Lesburg, C.A, Liang, R, Lim, J, Long, B.J, Lu, M, Ma, Y, Minnihan, E.C, Otte, R.D, O’Donnell, G, Pan, B.S, Perera, S.A, Piesvaux, J.A, Presland, J.P, Price, L, Rakhilina, L, Sauvagnat, B, Schroeder, G.K, Sharma, S, Trotter, B.W, Tyagarajan, S, Woo, H, Wyss, D.F, Xu, S, Addona, G.H, Bennett, D.J.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.5c00540

Primary Citation of related structures

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