9PN0 image
Deposition Date 2025-07-18
Release Date 2025-08-20
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9PN0
Keywords:
PEPTIDE BINDING PROTEIN
Title:
Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Unidentified baculovirus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9PN0 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Huntingtin
Gene (Uniprot):HTT
Chain IDs:D (auth: A)
Chain Length:3156
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P42858 Pfam ID:PF20926, PF20925, PF20927
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40-kDa huntingtin-associated
Gene (Uniprot):F8A1, F8A2, F8A3
Chain IDs:E (auth: B)
Chain Length:389
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P23610
Polymer Type:polypeptide(L)
Molecule:HHD3
Chain IDs:B (auth: C)
Chain Length:19
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:HD4
Chain IDs:A (auth: D)
Chain Length:19
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:HL2
Chain IDs:C (auth: E)
Chain Length:17
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Proc.Natl.Acad.Sci.USA 123 e2520462123 e2520462123 (2026)
PMID: 41838909 DOI: 10.1073/pnas.2520462123
Primary Citation of related structures
9PN0
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