9PLR image
Deposition Date 2025-07-16
Release Date 2026-07-22
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9PLR
Keywords:
LIGASE
Title:
CryoEM reconstruction of HUWE1-USP7 complex in the closed state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.88 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9PLR validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase H
Gene (Uniprot):HUWE1
Chain IDs:A
Chain Length:4374
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7Z6Z7 Pfam ID:PF06012, PF06025, PF22562, PF02825, PF14377, PF00632 EC:2.3.2.26
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin carboxyl-terminal h
Gene (Uniprot):USP7
Chain IDs:B (auth: C)
Chain Length:1102
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q93009 Pfam ID:PF22486, PF00443, PF12436, PF14533 EC:3.4.19.12
Ligand Molecules
NA
Primary Citation
Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins
To Be Published ? ? ? (?)
Primary Citation of related structures
9PLR
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