9PJ1 image
Deposition Date 2025-07-11
Release Date 2026-06-17
Last Version Date 2026-06-17
Entry Detail
PDB ID:
9PJ1
Keywords:
IMMUNE SYSTEM/Transferase/Isomerase
Title:
Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.05 Å
R-Value Free:
0.22
R-Value Work:
0.19
Space Group:
P 1 21 1
9PJ1 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):FKBP1A
Chain IDs:A (auth: C)
Chain Length:108
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62942 Pfam ID:PF00254 EC:5.2.1.8
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):MTOR
Chain IDs:B (auth: D)
Chain Length:92
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P42345 Pfam ID:PF08771 EC:2.7.11.1,2.7.10.2
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Heavy chain
Chain IDs:C (auth: H)
Chain Length:227
Number of Molecules:1
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Light chain
Chain IDs:D (auth: L)
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
RAP
Primary Citation
Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR
To Be Published ? ? ? (?)
Primary Citation of related structures
9PJ1
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