9PHV image
Deposition Date 2025-07-09
Release Date 2026-07-01
Last Version Date 2026-07-01
Entry Detail
PDB ID:
9PHV
Keywords:
OXIDOREDUCTASE
Title:
Crystal structure of human KDM2A with substrate competitive inhibitor 183c
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.16 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.18
Space Group:
P 31 2 1
9PHV validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Lysine-specific demethylase 2
Gene (Uniprot):KDM2A
Chain IDs:A
Chain Length:383
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2K7 Pfam ID:PF17811 EC:1.14.11.27
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Lysine-specific demethylase 2
Gene (Uniprot):KDM2A
Chain IDs:B (auth: D)
Chain Length:69
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2K7 Pfam ID:PF17811 EC:1.14.11.27
Ligand Molecules
A1CIP
AKG
DMS
GOL
NI
TRS
Primary Citation
Structural insights into the selective inhibition of KDM2A by compound 183c
To Be Published ? ? ? (?)
Primary Citation of related structures
9PHV
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