ISDA: 9P74

Deposition Date 2025-06-20

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9P74

Keywords:

TRANSFERASE

Title:

Crystal Structure of cGMP-dependent protein kinase from Plasmodium vivax in complex with inhibitor RUBP-61

Biological Source:

Source Organism(s):

Plasmodium vivax Sal-1 (Taxon ID: 126793)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.27

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:cGMP-dependent protein kinase
Chain IDs:A
Chain Length:863
Number of Molecules:1
Biological Source:Plasmodium vivax Sal-1

Ligand Molecules

A1CHG

GOL

Primary Citation

An orally available PfPKG inhibitor blocks Plasmodium's infection of the liver.

Dhiyebi, H, Mbaye, A, Thaniana, A, Gilleran, J, Eck, T, Ashraf, K, Kudyba, K, Fan, H, Seibold, S, Battaile, K.P, Siekierka, J, Johnson, E, Roth, A, De Rocher, A, Lovell, S, Miller, E.B, Roberge, J.Y, Bhanot, P.Show

Plos Pathog. 22 e1014322 e1014322 (2026)

PMID: 42531257 DOI: 10.1371/journal.ppat.1014322

Primary Citation of related structures

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