ISDA: 9OYA

Deposition Date 2025-06-04

Release Date 2026-08-12

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9OYA

Keywords:

HYDROLASE

Title:

Full LRRK2 (R1441C mutant) after symmetry expansion

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.44 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat serine/th
Mutagens:R1441C
Chain IDs:A (auth: B)
Chain Length:2527
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

GDP

Primary Citation

The structural basis for LRRK2's activation and autoinhibition.

Villagran Suarez, A, Hatch, K.S, Bodrug, T, Gai, W, Surridge, K.J, Moussikhina, E, Nguyen, K.H.V, Sanz-Murillo, M, Callahan, R, Xiong, E, Ramos, D, Zhu, L, Dederer, V, Mathea, S, Iwasa, J, Knapp, S, Shokat, K.M, Reck-Peterson, S.L, Leschziner, A.E.Show

Cell ? ? ? (2026)

PMID: 42575089 DOI: 10.1016/j.cell.2026.07.027

Primary Citation of related structures

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