ISDA: 9OX8

Deposition Date 2025-06-03

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9OX8

Keywords:

DNA BINDING PROTEIN/DNA

Title:

NHEJ Short-range complex with Polymerase lambda

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens, Escherichia coli, Unidentified baculovirus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

7.23 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA ligase 4
Gene (Uniprot):LIG4
Chain IDs:A, T (auth: X)
Chain Length:911
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49917 Pfam ID:PF04675, PF01068, PF04679, PF00533, PF11411 EC:6.5.1.1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Non-homologous end-joining fa
Gene (Uniprot):NHEJ1
Chain IDs:B, I
Chain Length:299
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9H9Q4 Pfam ID:PF09302, PF21928

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:X-ray repair cross-complement
Gene (Uniprot):XRCC6
Chain IDs:C, J
Chain Length:600
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P12956 Pfam ID:PF03731, PF02735, PF03730, PF02037 EC:3.6.4.-,4.2.99.-

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:X-ray repair cross-complement
Gene (Uniprot):XRCC5
Chain IDs:D, K
Chain Length:732
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P13010 Pfam ID:PF03731, PF02735, PF03730, PF08785

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA polymerase lambda
Gene (Uniprot):POLL
Chain IDs:E, F
Chain Length:575
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UGP5 Pfam ID:PF14716, PF10391, PF14792, PF14791 EC:4.2.99.B1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA repair protein XRCC4
Gene (Uniprot):XRCC4
Chain IDs:G, H, O, P
Chain Length:336
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q13426 Pfam ID:PF06632, PF21924, PF21925

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (34-MER)
Chain IDs:L, N
Chain Length:34
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (34-MER)
Chain IDs:M, Q
Chain Length:34
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein PAXX
Gene (Uniprot):PAXX
Chain IDs:R (auth: T), S (auth: U)
Chain Length:204
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9BUH6 Pfam ID:PF15384

Ligand Molecules

Primary Citation

End Processing in NHEJ by Polymerase lambda and PNKP is coordinated during short-range synapsis

Vogt, A, Kaminski, A.M, Pedersen, L.C, Naila, T, Tomkinson, A.E, Lees-Miller, S.P, Kunkel, T.A, He, Y.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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