9OVY image
Deposition Date 2025-06-01
Release Date 2026-06-10
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9OVY
Keywords:
TRANSFERASE
Title:
Cryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OVY validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein arginine N-methyltran
Gene (Uniprot):PRMT5
Chain IDs:A, C (auth: G), D (auth: E), F (auth: C)
Chain Length:637
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:O14744 Pfam ID:PF17285, PF05185, PF17286 EC:2.1.1.320
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Methylosome protein 50
Gene (Uniprot):WDR77
Chain IDs:B, E (auth: F), G (auth: D)
Chain Length:342
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q9BQA1 Pfam ID:PF00400
Ligand Molecules
65B
A1CEU
SAH
Primary Citation
Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment.
J Enzyme Inhib Med Chem 41 2727844 2727844 (2026)
PMID: 42710907 DOI: 10.1080/14756366.2026.2727844
Primary Citation of related structures
9OVY
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