ISDA: 9OU0

Deposition Date 2025-05-27

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

9OU0

Keywords:

HYDROLASE

Title:

K-Ras G12D 1-169 bound to MRTX-1133 at 277 K

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.81 Å

R-Value Free:

0.18

R-Value Work:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12D, C51S, C80L, C118S
Chain IDs:A, B
Chain Length:169
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

6IC

GDP

Primary Citation

Structures of Oncogenic KRAS-G12D bound to MRTX-1133

Xu, M, Deck, S.L, Milano, S.K, Cerione, R.A.Show

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Primary Citation of related structures

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