9OS5 image
Deposition Date 2025-05-23
Release Date 2025-09-03
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9OS5
Keywords:
IMMUNE SYSTEM, ANTIVIRAL PROTEIN
Title:
Human antibody Fab MPV498 bound to hMPV B2 post-fusion F
Biological Source:
Source Organism(s):
human metapneumovirus (Taxon ID: 162145)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.61 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OS5 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fusion glycoprotein F0
Gene (Uniprot):F
Chain IDs:A, B, C, D, E, F
Chain Length:465
Number of Molecules:6
Biological Source:human metapneumovirus
UniProt ID:Q6W8S4 Pfam ID:PF00523
Polymer Type:polypeptide(L)
Molecule:MPV498 Fab heavy chain
Chain IDs:G, I (auth: H), K (auth: I)
Chain Length:124
Number of Molecules:3
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:MPV498 Fab light chain
Chain IDs:H (auth: J), J (auth: K), L
Chain Length:100
Number of Molecules:3
Biological Source:Homo sapiens
Ligand Molecules
NAG
Primary Citation
Structural basis for childhood antibody recognition of the human metapneumovirus fusion protein.
Nat Commun 17 1267 1267 (2025)
PMID: 41455691 DOI: 10.1038/s41467-025-68021-8
Primary Citation of related structures
9OS5
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