ISDA: 9OPK

Deposition Date 2025-05-19

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9OPK

Keywords:

TRANSFERASE

Title:

Crystal structure of IRAK4 with compound 1, an analog of KT-474 TBM

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.20

R-Value Work:

0.15

R-Value Observed:

0.16

Space Group:

P 21 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Interleukin-1 receptor-associ
Gene (Uniprot):IRAK4
Chain IDs:A, B, C, D
Chain Length:304
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9NWZ3 Pfam ID:PF07714 EC:2.7.11.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
SEP	A	SER	modified residue
TPO	A	THR	modified residue

Ligand Molecules

A1CDD

EDO

GOL

Primary Citation

Structural basis for selective and potent degradation of IRAK4 by KT-474.

Fei, X, Ramanathan, A, Daigle, C.A, Ford, M, Campbell, V, Zheng, X, Sintchak, M, Li, H, Kamadurai, H, Miller, R, Kazmirski, S, Huang, X, Weiss, M.M, Mainolfi, N, Zhu, X.Show

Nat Commun ? ? ? (2026)

PMID: 42336816 DOI: 10.1038/s41467-026-74105-w

Primary Citation of related structures

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