9OPJ image
Deposition Date 2025-05-19
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9OPJ
Keywords:
Transferase/DNA-Binding Protein
Title:
cryoEM structure of IRAK4:KT-474:CRBN-DDB1 ternary complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OPJ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:1148
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16531 Pfam ID:PF10433, PF23726, PF03178
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B
Chain Length:405
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96SW2 Pfam ID:PF02190, PF03226
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interleukin-1 receptor-associ
Gene (Uniprot):IRAK4
Chain IDs:C (auth: Z)
Chain Length:461
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWZ3 Pfam ID:PF07714 EC:2.7.11.1
Ligand Molecules
A1CDC
ZN
Primary Citation
Structural basis for selective and potent degradation of IRAK4 by KT-474.
Nat Commun ? ? ? (2026)
PMID: 42336816 DOI: 10.1038/s41467-026-74105-w
Primary Citation of related structures
9OPJ
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