ISDA: 9OLC

Deposition Date 2025-05-12

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9OLC

Keywords:

TRANSCRIPTION

Title:

Crystal structure of PPARg ligand-binding domain in complex with NCoR1 peptide and FTX-6746

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Synthetic construct

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.83 Å

R-Value Free:

0.29

R-Value Work:

0.23

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peroxisome proliferator-activ
Gene (Uniprot):PPARG
Chain IDs:A, B, C, D
Chain Length:278
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P37231 Pfam ID:PF00104

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nuclear receptor corepressor
Gene (Uniprot):NCOR1
Chain IDs:E, F, G, H
Chain Length:13
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:O75376

Ligand Molecules

A1CCT

Primary Citation

Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers

Stuckey, J.I, Mertz, J.A, Wilson, J.E, Williamson, K.E, Li, Y, Kuljanin, M, Setser, J.W, DeLaBarre, B, Chenail, G, Nguyen, P.A, Bailey, C.M, Motley, W.W, Audia, J.E, Sims 3rd, R.J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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