9OK4 image
Deposition Date 2025-05-09
Release Date 2026-04-15
Last Version Date 2026-04-15
Entry Detail
PDB ID:
9OK4
Keywords:
PEPTIDE BINDING PROTEIN
Title:
GID4 in complex with CLEO4-88 and ACAA1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.28 Å
R-Value Free:
0.22
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 21 21 21
9OK4 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:3-ketoacyl-CoA thiolase, pero
Gene (Uniprot):ACAA1
Chain IDs:A, D (auth: B)
Chain Length:418
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P09110 Pfam ID:PF00108, PF02803
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucose-induced degradation p
Gene (Uniprot):GID4
Chain IDs:B (auth: C), C (auth: D)
Chain Length:167
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q8IVV7 Pfam ID:PF09783
Ligand Molecules
EDO
L6U
Primary Citation
The GID4 binder CLEO4-88 acts as an allosteric molecular glue that inhibits ACAA1 thiolase activity
To Be Published ? ? ? (?)
DOI: 10.1038/s41589-026-02183-4
Primary Citation of related structures
9OK4
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