ISDA: 9OIB

Deposition Date 2025-05-06

Release Date 2026-05-13

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9OIB

Keywords:

SIGNALING PROTEIN

Title:

Mouse LRRC15 extracellular domain

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.26 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat-containin
Gene (Uniprot):Lrrc15
Mutagens:C418S
Chain IDs:A
Chain Length:458
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:Q80X72 Pfam ID:PF13855

Ligand Molecules

GOL

Primary Citation

Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts.

Tombling, B.J, Cai, F, Wendorff, T.J, Ogasawara, A, Gill, H.S, Tinianow, J.N, Chang, A, Balana, A.T, Peng, L, Miller, S.E, Walters, B.T, Lictao, A, Yu, Q, DeWitt, D.C, Wei, Y, Wu, S.Z, Sudhamsu, J, Krishnamurty, A.T, Williams, S.P, Marik, J, Zhang, Y, Maun, H.R, Kirchhofer, D.Show

Nat Commun 17 ? ? (2026)

PMID: 42248838 DOI: 10.1038/s41467-026-73845-z

Primary Citation of related structures

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