ISDA: 9OHN

Deposition Date 2025-05-05

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9OHN

Keywords:

HYDROLASE/HYDROLASE INHIBITOR

Title:

Cryo-EM structure of human p97/VCP bound to inhibitor GND-135

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.46 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transitional endoplasmic reti
Gene (Uniprot):VCP
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:821
Number of Molecules:12
Biological Source:Homo sapiens

UniProt ID:P55072 Pfam ID:PF02359, PF02933, PF00004, PF17862 EC:3.6.4.6

Ligand Molecules

A1CBF

ADP

Primary Citation

Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor

Crawford, J, Munuganti, R, Leung, C, Singh, K, Gates, E, Zhu, X, Bally, M, Dos Santos, N, Sharifiaghdam, M, Nosrati, Z, Axerio-Cilies, P, Berezuk, A, Cholak, S, Cameron, D, Subramaniam, S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form