9OH4 image
Deposition Date 2025-05-02
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9OH4
Keywords:
TRANSFERASE/DNA
Title:
Cryo-EM structure of cGAS tetramer in complex with BuDNA (bubble DNA)
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.48 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OH4 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclic GMP-AMP synthase
Gene (Uniprot):Cgas
Chain IDs:A, B, C, D
Chain Length:357
Number of Molecules:4
Biological Source:Mus musculus
UniProt ID:Q8C6L5 Pfam ID:PF03281, PF20266 EC:2.7.7.86
Polymer Type:polydeoxyribonucleotide
Molecule:Bubble DNA Forward(41-MER)
Chain IDs:E, G
Chain Length:41
Number of Molecules:2
Biological Source:synthetic construct
Polymer Type:polydeoxyribonucleotide
Molecule:Bubble DNA Reverse(41-MER)
Chain IDs:F, H
Chain Length:41
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
ZN
Primary Citation
The Cryo-EM structure of cGAS tetramer in complex with BuDNA (bubble DNA)
To Be Published ? ? ? (?)
Primary Citation of related structures
9OH4
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