ISDA: 9OGM

Deposition Date 2025-05-01

Release Date 2025-07-30

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9OGM

Keywords:

VIRAL PROTEIN/Immune System

Title:

BG505 MD39.3 Env gp151 MPER nanodisc in complex with 10E8, BG18 and VRC01 Fabs (1x 10E8 Fab)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Human immunodeficiency virus 1 (Taxon ID: 11676)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein gp160
Gene (Uniprot):env, env
Chain IDs:N (auth: A), O (auth: B), P (auth: C)
Chain Length:735
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

UniProt ID:Q2N0S6,A0A6H1VGN1 Pfam ID:PF00516, PF00517

Polymer Type:polypeptide(L)
Molecule:BG18 Fab heavy chain
Chain IDs:A (auth: D), C (auth: F), F (auth: I)
Chain Length:233
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:BG18 Fab light chain
Chain IDs:B (auth: E), D (auth: G), G (auth: J)
Chain Length:214
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:10E8 Fab heavy chain
Chain IDs:E (auth: H)
Chain Length:236
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:VRC01 Fab heavy chain
Chain IDs:H (auth: K), K (auth: N), L (auth: P)
Chain Length:224
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:10E8 Fab light chain
Chain IDs:I (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:VRC01 Fab light chain
Chain IDs:J (auth: M), M (auth: Q), Q (auth: O)
Chain Length:210
Number of Molecules:3
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Virus glycoprotein nanodisc platform for vaccine analytics.

Rantalainen, K, Liguori, A, Ozorowski, G, Flynn, C, Steichen, J.M, Swanson, O.M, Madden, P.J, Baboo, S, Phulera, S, Gharpure, A, Lu, D, Kalyuzhniy, O, Skog, P, Terada, S, Shil, M, Diedrich, J.K, Georgeson, E, Tingle, R, Eskandarzadeh, S, Lee, W.H, Alavi, N, Goodwin, D, Kubitz, M, Amirzehni, S, Himansu, S, Sok, D, Lee, J.H, Yates 3rd, J.R, Paulson, J.C, Crotty, S, Schiffner, T, Ward, A.B, Schief, W.R.Show

Nat Commun 17 ? ? (2026)

PMID: 41667448 DOI: 10.1038/s41467-026-68985-1

Primary Citation of related structures

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