ISDA: 9OGI

Deposition Date 2025-04-30

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9OGI

Keywords:

TRANSCRIPTION/INHIBITOR

Title:

Structure of TEAD2 bound to G8025

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.25 Å

R-Value Free:

0.25

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transcriptional enhancer fact
Gene (Uniprot):TEAD2
Chain IDs:A, B
Chain Length:250
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q15562 Pfam ID:PF17725

Ligand Molecules

A1CA7

Primary Citation

Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model.

Hagenbeek, T.J, Zbieg, J, Smith, R, Paul, S, Gerosa, L, Torrini, C, Guarnaccia, A.D, Ong, C, Lacap, J.A, Ning, M, Sodir, N.M, Hafner, M, Tremblay, J, Hawley, J, Chan, B, Verma, V.A, Beveridge, R.E, Hsu, P.L, Ulas, G, Wang, L, Nonomiya, J, Chen, S, Pham, V, Webster, J, Preston, J, Hung, J, Eastham, J, Dunlap, D, Lee, W, Beroza, P, Nayyar, N, Martin, S, Lin, E, Weng, J, Foster, S.A, Shanahan, F, Fong, R, Boenig, G, Di Lello, P, Kubala, M.H, Hunsaker, T, Ravichandran, M, Saenz-Lopez Larrocha, P, Lau, J, An, L, Levy, E, Lorenzo, M.N, Lill, J.R, Modrusan, Z.D, Chen, Y.C, Yao, X, Brastianos, P.K, Maddalo, D, Dey, A.Show

Nat Commun ? ? ? (2026)

PMID: 42365001 DOI: 10.1038/s41467-026-74722-5

Primary Citation of related structures

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