ISDA: 9OGA

Deposition Date 2025-04-30

Release Date 2025-11-26

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9OGA

Keywords:

PROTEIN TRANSPORT

Title:

Cryo-EM structure of human full-length XPO1 conjugated with selinexor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.37 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Exportin-1
Gene (Uniprot):XPO1
Chain IDs:A
Chain Length:1073
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O14980 Pfam ID:PF03810, PF08389, PF18777, PF18784, PF18787, PF08767

Ligand Molecules

V6A

Primary Citation

SINE compounds activate exportin 1 degradation through an allosteric mechanism.

Wing, C.E, Fung, H.Y.J, Kwanten, B, Cagatay, T, Niesman, A.B, Jacquemyn, M, Gharghabi, M, Permentier, B, Shakya, B, Nandi, R, Ready, J.M, Kashyap, T, Shacham, S, Landesman, Y, Lapalombella, R, Daelemans, D, Chook, Y.M.Show

Nat.Chem.Biol. 21 2002 2013 (2025)

PMID: 41286136 DOI: 10.1038/s41589-025-02058-0

Primary Citation of related structures

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