9OFU image
Deposition Date 2025-04-30
Release Date 2025-06-11
Last Version Date 2026-08-19
Entry Detail
PDB ID:
9OFU
Keywords:
DNA BINDING PROTEIN
Title:
Dimer of HIF-1a-ARNT Heterodimers Complexed on 52-bp HRE/HAS
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OFU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Hypoxia-inducible factor 1-al
Gene (Uniprot):HIF1A
Chain IDs:A, C
Chain Length:373
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q16665 Pfam ID:PF00989, PF08447, PF23171
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aryl hydrocarbon receptor nuc
Gene (Uniprot):ARNT
Chain IDs:B, D
Chain Length:381
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P27540 Pfam ID:PF00010, PF00989, PF14598
Polymer Type:polydeoxyribonucleotide
Molecule:52-nt Hypoxia Response Elemen
Chain IDs:E
Chain Length:52
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polydeoxyribonucleotide
Molecule:52-nt Hypoxia Response Elemen
Chain IDs:F
Chain Length:52
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners.
Proc.Natl.Acad.Sci.USA 123 e2514042123 e2514042123 (2026)
PMID: 42048441 DOI: 10.1073/pnas.2514042123
Primary Citation of related structures
9OFU
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