9OF0 image
Deposition Date 2025-04-29
Release Date 2025-06-11
Last Version Date 2026-08-19
Entry Detail
PDB ID:
9OF0
Keywords:
DNA BINDING PROTEIN
Title:
Cryo-EM Structure of Human HIF-2a-ARNT Complexed on 20-bp HRE
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OF0 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Endothelial PAS domain-contai
Gene (Uniprot):EPAS1
Chain IDs:A
Chain Length:372
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99814 Pfam ID:PF00989, PF14598, PF23171
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aryl hydrocarbon receptor nuc
Gene (Uniprot):ARNT
Chain IDs:B
Chain Length:381
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P27540 Pfam ID:PF00010, PF00989, PF14598
Polymer Type:polydeoxyribonucleotide
Molecule:20-nt Hypoxia Response Elemen
Chain IDs:C
Chain Length:21
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polydeoxyribonucleotide
Molecule:20-nt Hypoxia Response Elemen
Chain IDs:D
Chain Length:21
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners.
Proc.Natl.Acad.Sci.USA 123 e2514042123 e2514042123 (2026)
PMID: 42048441 DOI: 10.1073/pnas.2514042123
Primary Citation of related structures
9OF0
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