ISDA: 9OBB

Deposition Date 2025-04-22

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

9OBB

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of dihydroorotate dehydrogenase from Leishmania brasiliensis in complex with 5-[(E)-3-(p-methoxyphenyl)-2-propenylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione

Biological Source:

Source Organism(s):

Leishmania braziliensis (Taxon ID: 5660)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.32 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydroorotate dehydrogenase
Gene (Uniprot):DHODH
Chain IDs:A, B
Chain Length:347
Number of Molecules:2
Biological Source:Leishmania braziliensis

UniProt ID:E9AI53 Pfam ID:PF01180

Ligand Molecules

5TI

FMN

Primary Citation

Crystal structure of dihydroorotate dehydrogenase from Leishmania brasiliensis in complex with 5-[(E)-3-(p-methoxyphenyl)-2-propenylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione

Vaidergorn, M.M, Nonato, M.C, Froes, T.Q, Augusto, B.S.Show

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