ISDA: 9O8L

Deposition Date 2025-04-16

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

9O8L

Keywords:

MEMBRANE PROTEIN

Title:

CryoEM Structure of Gq-coupled MRGPRX1 in complex with de novo protein mM1_060 (E12)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.13 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:MiniGsq71
Chain IDs:C (auth: A)
Chain Length:246
Number of Molecules:1
Biological Source:Escherichia coli

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:E (auth: B)
Chain Length:345
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:F (auth: C)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:D (auth: E)
Chain Length:257
Number of Molecules:1
Biological Source:Escherichia coli

Polymer Type:polypeptide(L)
Molecule:De novo protein mM1_060 (E12)
Chain IDs:B (auth: F)
Chain Length:50
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mas-related G-protein coupled
Gene (Uniprot):MRGPRX1
Chain IDs:A (auth: R)
Chain Length:322
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96LB2

Ligand Molecules

Primary Citation

CryoEM Structure of Gq-coupled MRGPRX1 in complex with de novo proteins

Krumm, B.E, Roth, B.L.Show

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Primary Citation of related structures

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