ISDA: 9O6B

Deposition Date 2025-04-11

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9O6B

Keywords:

TRANSCRIPTION

Title:

X-Ray structure of F240L mutant HOXB13 in complex with DNA (CAA)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Homeobox protein Hox-B13
Gene (Uniprot):HOXB13
Mutagens:F240L
Chain IDs:A (auth: J), D (auth: A)
Chain Length:101
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q92826 Pfam ID:PF00046

Polymer Type:polydeoxyribonucleotide
Molecule:DNA-TTGTGTTTTATTGGGTCC
Chain IDs:B (auth: K), E (auth: B)
Chain Length:18
Number of Molecules:2
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA-GGACCCAATAAAACACAA
Chain IDs:C (auth: L), F (auth: C)
Chain Length:18
Number of Molecules:2
Biological Source:synthetic construct

Primary Citation

Structural and Biochemical Characterization of HOXB13 Homeobox Domain Germline Mutations Driving Prostate Cancer

Dikbas, U.M, Wong, J.T, Chen, Y.S, Lallous, N, Van Petegem, F, Lack, N.A.Show

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Primary Citation of related structures

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