ISDA: 9O69

Deposition Date 2025-04-11

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

9O69

Keywords:

HYDROLASE

Title:

Crystal Structure of human Cathepsin K co-crystalized with Nirmatrelvir

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Pichia

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.19

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cathepsin K
Gene (Uniprot):CTSK
Chain IDs:A
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43235 EC:3.4.22.38

Ligand Molecules

4WI

EDO

Primary Citation

Potential role of cathepsins in SARS-CoV-2 infections and the dual activity of nirmatrelvir as 3CLMpro and cathepsin inhibitor

Tabatabaei, Y, Saha, D, Chen, Y.S, Niikura, M, Panwar, P, Mar, E, Van Petegem, F, Bromme, D.Show

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Primary Citation of related structures

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