ISDA: 9NZ2

Deposition Date 2025-03-31

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

9NZ2

Keywords:

IMMUNE SYSTEM/VIRAL PROTEIN

Title:

Cryo-EM structure of antibody 22F5 in complex with pre-fusion stabilized LayV-F

Biological Source:

Source Organism(s):

Langya virus (Taxon ID: 2971765)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.46 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fusion glycoprotein F0
Gene (Uniprot):F
Mutagens:G99C, I109C
Chain IDs:A, B, C
Chain Length:563
Number of Molecules:3
Biological Source:Langya virus

UniProt ID:A0AAX3C923

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Antibody 22F5 Heavy Chain
Chain IDs:D, F, I
Chain Length:216
Number of Molecules:3
Biological Source:Mus musculus

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Antibody 22F5 Kappa Light Cha
Chain IDs:E, G, H
Chain Length:219
Number of Molecules:3
Biological Source:Mus musculus

Ligand Molecules

NAG

Primary Citation

Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins.

May, A.J, Lella, M, Lindenberger, J, Berkman, A, Kumar, U, Dutta, M, Barr, M, Parks, R, Lu, X, Berry, M, Newman, A, Huang, X, Song, K, Ilevbare, V, Sammour, S, Park, C.S, Adhikari, R.D, Devkota, P, Janowska, K, Liu, Y, Scapellato, G, Spence, T.N, Mansouri, K, Wiehe, K, Edwards, R.J, Saunders, K.O, Haynes, B.F, Acharya, P.Show

bioRxiv ? ? ? (2025)

DOI: 10.1101/2024.12.11.627382

Primary Citation of related structures

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