9NSO image
Deposition Date 2025-03-17
Release Date 2026-03-25
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9NSO
Keywords:
PROTEIN BINDING
Title:
Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-41060
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.85 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 21 21 21
9NSO validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:B (auth: A)
Chain Length:329
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61964 Pfam ID:PF25175
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DDB1- and CUL4-associated fac
Gene (Uniprot):DCAF1
Chain IDs:A (auth: B)
Chain Length:338
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y4B6
Ligand Molecules
A1B0Y
Primary Citation
Structural basis for the cooperative binding of DCAF1-PROTAC-WDR5 ternary complexes
To be published ? ? ? (?)
Primary Citation of related structures
9NSN
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