9NQL image
Deposition Date 2025-03-12
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9NQL
Keywords:
HYDROLASE/ANTIBIOTIC
Title:
Cryo electron microscopic analysis of the adduct of syringolin analog with the Mtb 20S proteasome
Biological Source:
Source Organism(s):
Mycobacterium tuberculosis (Taxon ID: 1773)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.16 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NQL validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Chain IDs:A (auth: 1), B (auth: 2), Q (auth: O), R (auth: P), S (auth: Q), T (auth: R), U (auth: S), V (auth: T), W (auth: U), X (auth: V), Y (auth: W), Z (auth: X), AA (auth: Y), BA (auth: Z)
Chain Length:240
Number of Molecules:14
Biological Source:Mycobacterium tuberculosis
Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha
Chain IDs:C (auth: A), D (auth: B), E (auth: C), F (auth: D), G (auth: E), H (auth: F), I (auth: G), J (auth: H), K (auth: I), L (auth: J), M (auth: K), N (auth: L), O (auth: M), P (auth: N)
Chain Length:240
Number of Molecules:14
Biological Source:Mycobacterium tuberculosis
Ligand Molecules
A1B0M
Primary Citation
Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages
Acs Chem.Biol. ? ? ? (2026)
DOI: 10.1021/acschembio.6c00448
Primary Citation of related structures
9NQL
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