9NID image
Deposition Date 2025-02-26
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9NID
Keywords:
Transferase/Hydrolase
Title:
Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex dimer on POPC/POPS/PIP2 nanodiscs low-pass filtered to 5 angstroms
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda, Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
5.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NID validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 4,5-bisp
Gene (Uniprot):PIK3CA
Chain IDs:A, B
Chain Length:1096
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P42336 Pfam ID:PF02192, PF00794, PF00792, PF00613, PF00454 EC:2.7.1.137
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Chain IDs:C, D
Chain Length:188
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2
Ligand Molecules
A1AZD
GNP
MG
Primary Citation
Structures of the PI3K alpha /KRas complex on lipid bilayers reveal the molecular mechanism of PI3K alpha activation.
Biorxiv ? ? ? (2025)
PMID: 40196507 DOI: 10.1101/2025.03.22.644753
Primary Citation of related structures
9NID
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