ISDA: 9NI6

Deposition Date 2025-02-25

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9NI6

Keywords:

ONCOPROTEIN

Title:

Cryo-EM structure of the Class 1 PI3K alpha/KRas complex on POPC/POPS nanodiscs

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda, Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.01 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 4,5-bisp
Gene (Uniprot):PIK3CA
Chain IDs:B (auth: A)
Chain Length:1096
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P42336 Pfam ID:PF02192, PF00794, PF00792, PF00613, PF00454 EC:2.7.1.137

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 3-kinase
Gene (Uniprot):PIK3R1
Chain IDs:A (auth: B)
Chain Length:724
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P27986 Pfam ID:PF00620, PF00017, PF16454 EC:2.7.1.153

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Chain IDs:C
Chain Length:189
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules