ISDA: 9NHP

Deposition Date 2025-02-24

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9NHP

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

GB-0669 Fab: S2 stem helix peptide

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.93 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 32 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:GB-0669 Fab Heavy Chain
Chain IDs:B (auth: H)
Chain Length:231
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:GB-0669 Fab Light Chain
Chain IDs:A (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Spike protein S2
Chain IDs:C (auth: P)
Chain Length:19
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

Primary Citation

Functional and structural characterization of a combination of a combination of pan-sarbecovirus antibodies with potent antiviral activity

Marden, G.C, Schmitt, K.P, Zimmerman, M.I, Ramos, A.H, Menzenski, M.Z, Sharma, G, Li, H, Carlin, E, Jecrois, A, Morales-Perez, C.L, Palovcak, E, Garlick, J.D, Hannigan, B, Russell, P, Federman, R.S, Leung, A, Vargas, N.L, Shaban, N.M, Vaidya, V, Towler, H, Joh, N, Lord, D.M, Tao, J, Costello, Z, Frappier, V, Hopson, K, Pegu, A, Koh, G, Van Epps, H, Root, A, Grigoryan, G, Hazuda, D, Borriello, F.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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