9NEE image
Deposition Date 2025-02-19
Release Date 2025-08-13
Last Version Date 2026-02-25
Entry Detail
PDB ID:
9NEE
Keywords:
REPLICATION, TRANSFERASE/INHIBITOR
Title:
The flexible portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with Pritelivir
Biological Source:
Source Organism(s):
Herpesviridae (Taxon ID: 10292)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NEE validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA primase
Gene (Uniprot):UL52
Chain IDs:A
Chain Length:1058
Number of Molecules:1
Biological Source:Herpesviridae
UniProt ID:P10236 Pfam ID:PF03121
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA replication helicase
Gene (Uniprot):HELI
Chain IDs:B
Chain Length:846
Number of Molecules:1
Biological Source:Herpesviridae
UniProt ID:P10189 Pfam ID:PF02689
Ligand Molecules
A1BXB
Primary Citation
Structural and mechanistic insights into herpesvirus helicase-primase and its therapeutic inhibitors.
Nat Microbiol 10 3191 3201 (2025)
PMID: 41188384 DOI: 10.1038/s41564-025-02168-4
Primary Citation of related structures
9NEE
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