ISDA: 9NDA

Deposition Date 2025-02-17

Release Date 2025-08-13

Last Version Date 2026-02-25

Entry Detail

PDB ID:

9NDA

Keywords:

REPLICATION, TRANSFERASE

Title:

The rigid portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with amenamevir

Biological Source:

Source Organism(s):

Herpesviridae (Taxon ID: 10292)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA primase
Gene (Uniprot):UL52
Chain IDs:A
Chain Length:1057
Number of Molecules:1
Biological Source:Herpesviridae

UniProt ID:P10236 Pfam ID:PF03121

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA helicase/primase complex-
Gene (Uniprot):UL8
Chain IDs:B (auth: C)
Chain Length:747
Number of Molecules:1
Biological Source:Herpesviridae

UniProt ID:P10192 Pfam ID:PF03324

Ligand Molecules

Primary Citation

Structural and mechanistic insights into herpesvirus helicase-primase and its therapeutic inhibitors.

Yao, Q, Mercier, A, Nayak, A, May, L, Ho, P.Y, Lewis-Ballester, A, Nair, V, Sapre, A, Aeschbacher, T, Mukherjee, J, Richards, C, Mateo, R, Cho, A, Lansdon, E, Yu, X.Show

Nat Microbiol 10 3191 3201 (2025)

PMID: 41188384 DOI: 10.1038/s41564-025-02168-4

Primary Citation of related structures

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