9NCO image
Deposition Date 2025-02-16
Release Date 2026-02-18
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9NCO
Keywords:
SIGNALING PROTEIN
Title:
IN-ML-15 bound to IGF1Rzip
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Cricetulus griseus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NCO validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Insulin-like growth factor 1
Gene (Uniprot):IGF1R
Chain IDs:A, B
Chain Length:896
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P08069 Pfam ID:PF01030, PF00757 EC:2.7.10.1
Polymer Type:polypeptide(L)
Molecule:IN-ML-15 beta
Chain IDs:C
Chain Length:30
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:IN-ML-15 alpha
Chain IDs:D
Chain Length:21
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.
Sci Adv 12 eaeb7558 eaeb7558 (2026)
PMID: 42139356 DOI: 10.1126/sciadv.aeb7558
Primary Citation of related structures
9NCO
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