ISDA: 9N8Y

Deposition Date 2025-02-10

Release Date 2026-09-09

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9N8Y

Keywords:

MEMBRANE PROTEIN

Title:

Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.76 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Metabotropic glutamate recept
Gene (Uniprot):GRM8
Chain IDs:A, B
Chain Length:839
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O00222 Pfam ID:PF01094, PF07562, PF00003

Ligand Molecules

A1BWG

E7P

Primary Citation

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.

Marx, D.C, Huynh, K, Gonzalez-Hernandez, A.J, Strauss, A, Rico, C, Gallo, P.N, Sharghi Moshtaghin, S, Arefin, A, Broichhagen, J, Eliezer, D, Khelashvili, G, Levitz, J.Show

Nat Commun 17 ? ? (2026)

PMID: 42722693 DOI: 10.1038/s41467-026-77556-3

Primary Citation of related structures

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